Morphological Characteristics of the Thymus and Spleen and the Subpopulation Composition of Lymphocytes in Peripheral Blood during Systemic Inflammatory Response in Male Rats with Different Resistance to Hypoxia

Table 3

Subpopulation of lymphocytes in the peripheral blood of tolerant- (T) and susceptible- (S) to-hypoxia Wistar rats in 3, 6, and 24 hours after LPS injection. Data are presented as median (25%, 75%); the statistical significance of differences (p) between tolerant and susceptible rats is determined by the Mann-Whitney test and between different time points after LPS injection by the Kruskal-Wallis method ( = 5 in each group).

Lymphocyte subpopulation	Group	Control group^1	LPS injection			p(p<0.05)
			3 h^2	6 h^3	24 h^4
CD3+; Т-lymphocytes,; % from lymphocytes	T	38.0	42.3	44.6	51.2
		(28.4–45.9)	(35.1–51.8)	(25.3–45.2)	(40.0–57.9)
	S	53.6	55.8	43.0	46.0
		(44.2–54.1)	(48.5–56.4)	(37.9–45.9)	(40.2–51.5)
	p	0.14	0.25	0.33	0.38
CD3+CD4+; Т-helper cells,; % from; T-lymphocytes	T	57.5	46.1	20.3	42.2	0.02^1-3
		(49.0–66.3)	(42.0–51.5)	(16.4–21.2)	(29.8–50.4)
	S	29.8	44.8	22.1	46.3
		(23.2–34.4)	(34.3–61.0)	(21.3–23.8)	(43.1–50.5)
	p	0.06	0.75	0.33	0.51
CD3+CD8+ cytotoxic; Т-lymphocytes,; % from; T-lymphocytes	T	40.8	52.7	76.6	54.6	0.02^1-3
		(31.8–49.3)	(47.7–57.2)	(74.0–82.6)	(46.3–67.7)
	S	69.5	53.6	73.8	52.9
		(63.5–76.1)	(37.8–62.9)	(69.4–76.8)	(46.2–54.6)
	p	0.06	0.75	0.62	0.66
CD4+CD25+; Foxp3+; regulatory; Т-cells,; % from; T-helpers	T	2.1	1.0	0.7	2.2
		(2.05–2.4)	(0.8–1.3)	(0.5–0.7)	(1.5–2.7)
	S	1.8	1.2	1.1	1.9
		(1.5–2.7)	(0.6–1.2)	(1.0–1.2)	(0.9–2.1)
	p	0.62	0.92	0.39	0.34
CD314+ NK,; % from lymphocytes	T	8.6	15.6	29.6	27.3	0.03^1-3
		(8.3–12.7)	(11.6–19.9)	(26.0–37.1)	(15.8–30.7)
	S	15.4	9.6	28.8	17.6	0.003^2-3
		(15.4–22.1)	(6.5–13.4)	(26.1–30.2)	(16.7–18.1)
	p	0.33	0.14	0.65	0.56
CD45+; В-lymphocytes,; % from lymphocytes	T	25.3	14.5	9.3	20.8	0.03^1-3
		(19.4–27.8)	(5.9–15.3)	(5.6–11.5)	(19.5–22.0)	0.03^3-4
	S	17.1	6.4	10.1	25.2	0.003^2-4
		(13.2–20.2)	(4.9–8.6)	(8.9–10.5)	(25.2–27.7)	0.02^3-4
	p	0.09	0.33	0.88	0.03