Review Article
Epigenetics and Inflammatory Markers: A Systematic Review of the Current Evidence
Table 1
Global DNA methylation and inflammatory markers.
| Author, Year | Study design | Outcome | Tissue type | Population Sex/Age/Sample size/Country | Adjustment | Main findings |
| LINE-1 methylation | | | | | |
| Baccarelli et al., 2010 [16] | CS | VCAM-1, ICAM-1 and CRP | WB | M /73.8 ± 6.7/n=593/USA | Age, BMI, smoking, pack years of smoking, IHD or stroke. | Inverse association for VCAM-1. No association for ICAM-1 and CRP. |
| Perng et al., 2012 [17] | CS | CRP | WBC | M and W/ 8.8 ± 1.7/n=568/ Colombia | Sex, vitamin A, maternal BMI and household socioeconomic stratum. | Higher CRP was related to lower LINE-1 methylation. |
| Zhang et al., 2012 [14] | CS | CRP | WBC | M and W/ 18-78/n=165/USA | | No association (β coefficient=-0.02, p=0.81). |
| Narayan & Dangi, 2017 [18] | CS | CRP | WB | M and W/7.9 ± 1.5/n=600/India | Sex, plasma Vitamin A, socioeconomic status | Global DNA methylation was inversely related to CRP concentrations and the association was stronger in male children. |
| 5mdC | | | | | |
| Murphy et al., 2015 [19] | CS | IL-6 (protein and serum levels) | WB | M and W/mean=33.04/ n=47/Ireland | | No association (r = -0.125, p=0.46). |
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CS: cross-sectional; VCAM-1: vascular cell adhesion molecule 1; ICAM-1: intercellular adhesion molecule 1; CRP: C-Reactive protein; WB: whole blood; M: men; BMI: body mass index; WBC: white blood cells; IL: interleukin; W: women.
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