-Equol, a Major Isoflavone from Soybean, Inhibits Nitric Oxide Production in Lipopolysaccharide-Stimulated Rat Astrocytes Partially via the GPR30-Mediated Pathway

Figure 5

Effect of S-equol on LPS-induced MAPK expression. Cultured astrocytes were treated with LPS (1 μg/ml) with or without S-equol (50 μM) for 1, 3, and 6 h, and then the expressions of phosphorylated and total p38-MAPK (a–c) and ERK1/2 (d–f) proteins were detected with western blotting. In case of ERK1/2, total density of two bands was analyzed. Data are the mean ± SEM of 4 samples. ; significantly different from the nontreated control. significantly different from S-equol.

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