-Equol, a Major Isoflavone from Soybean, Inhibits Nitric Oxide Production in Lipopolysaccharide-Stimulated Rat Astrocytes Partially via the GPR30-Mediated Pathway

Figure 4

Effect of S-equol on LPS-induced ROS production. Cultured astrocytes were treated with LPS (1 μg/ml) in the absence or presence of 50 μM S-equol for 3, 6, and 24 h, and the intracellular ROS levels were evaluated using the DCFDA method (a). Effect of isoflavones (S-equol, genistein, and daidzein, each concentration of 50 μM) on LPS-induced ROS production at 6 h after LPS treatment (b). Data are the mean ± SEM of 5 samples. ; significantly different from the nontreated control. significantly different from S-equol.

(a)

(b)