Oxidative Stress, Vascular Remodeling, and Vascular Inflammation in Hypertension
1Department of Pathology and IMBECU-CONICET, National University of Cuyo, Mendoza, Argentina
2Department of Physiology, Complutense University of Madrid, Madrid, Spain
Oxidative Stress, Vascular Remodeling, and Vascular Inflammation in Hypertension
Description
Hypertension is a major public health problem worldwide, affecting over 50 million individuals in the United States alone. It is a major risk factor for target organ damage resulting in coronary artery disease, heart failure, stroke, and kidney disease. A major goal of basic hypertension research is to identify the underlying biological pathways and mechanisms responsible for abnormalities in blood pressure control, related risk factors, comorbidities, and susceptibility to target organ damage. Genetic studies over the past decade have demonstrated the enormous complexity involved in understanding the causes of high blood pressure. It has become clear that no single approach will answer the key questions related to the biological mechanisms underlying high blood pressure. Hence, interdisciplinary research models emphasizing all levels of inquiry, from the gene to the intact organism, are now required to yield the important and much needed data on the causes of high blood pressure and target organ damage. Potential topics include, but are not limited to:
- Physiopathology of vascular changes
- Participation of local and systemic inflammation in hypertension
- New pharmacological therapies
- The role of endothelial progenitor cells in damage and repair
- Role of nutrition (macro- and micro-nutrients) in the development and maintenance of blood pressure
- New advances in oxidative stress
- Clinical research
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