International Journal of Hypertension / 2016 / Article / Tab 6

Research Article

The Hypertension of Hemophilia Is Not Explained by the Usual Cardiovascular Risk Factors: Results of a Cohort Study

Table 6

Analyses of covariance comparing DBP values of untreated (not taking antihypertensive medications) PWH and NHANES subjects after adjusting for age and each covariate.

Covariate⁢Regression coefficient for Z (PWH versus NHANES)
95% CI

Young adults (18–29 years)
 No covariates (Cage + Cage2 + only)9.036.80, 11.25<0.0010.113
 log BMI8.596.80, 10.38<0.0010.167
 log (1 + Creatinine)8.917.06, 10.76<0.0010.159
 eGFR8.927.08, 10.77<0.0010.159
 log TotalCholesterol8.976.66, 11.28<0.0010.123
 Smoking status8.286.13, 10.43<0.0010.121
 HCV8.186.01, 10.35<0.0010.156
 Race8.526.77, 10.27<0.0010.162
 All covariates10.387.43, 13.33<0.0010.163

Older adults (30–79 years)
 No covariates (Cage + Cage2 + only)2.991.21, 4.770.0010.035
 log BMI4.543.04, 6.03<0.0010.083
 log (1 + Creatinine)4.182.62, 5.73<0.0010.049
 eGFR4.102.54, 5.65<0.0010.047
 log TotalCholesterol4.032.14, 5.91<0.0010.050
 Smoking status3.151.43, 4.87<0.0010.039
 HCV2.45−0.14, 5.040.0640.045
 Race0.062
 All covariates0.121
 All covariates except HCV0.116

indicates the binary variable that distinguishes PWH from NHANES ( for PWH, for NHANES); PWH, patients with hemophilia; NHANES, subjects from the National Health and Nutrition Examination Survey of the general United States population; , regression coefficient for representing change in log SBP per unit increase of the selected covariate; CI, confidence interval; , square of the multiple correlation coefficient; BMI, body mass index; eGFR, estimated glomerular filtration rate; HCV, hepatitis C virus.
Cage, Cage2, log BMI, eGFR, log TotalCholesterol, smoking status, HCV, and race.
race interaction was significant and therefore ANCOVA cannot be performed.

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