The Hypertension of Hemophilia Is Not Explained by the Usual Cardiovascular Risk Factors: Results of a Cohort Study
Table 4
Analyses of covariance comparing log SBP values of untreated (not taking antihypertensive medications) PWH and NHANES subjects after adjusting for age and each covariate.
Covariate
Regression coefficient for (PWH versus NHANES)
95% CI
Young adults (18–29 years)
No covariates (age + only)
0.069
0.050, 0.088
<0.001
0.085
log BMI
0.073
0.058, 0.088
<0.001
0.177
log (1 + Creatinine)
0.068
0.052, 0.084
<0.001
0.110
eGFR
0.068
0.052, 0.084
<0.001
0.110
log TotalCholesterol
0.079
0.060, 0.098
<0.001
0.094
Smoking status
0.071
0.052, 0.089
<0.001
0.087
HCV
0.066
0.048, 0.085
<0.001
0.104
Race
0.068
0.053, 0.083
<0.001
0.101
All covariates
0.081
0.057, 0.105
<0.001
0.159
Older adults (30–79 years)
No covariates (age + only)
0.031
0.013, 0.049
<0.001
0.041
log BMI
0.046
0.030, 0.061
<0.001
0.087
log (1 + Creatinine)
0.038
0.022, 0.054
<0.001
0.052
eGFR
0.037
0.020, 0.053
<0.001
0.052
log TotalCholesterol
0.036
0.017, 0.056
<0.001
0.060
Smoking status
0.035
0.017, 0.052
<0.001
0.043
HCV
0.012
−0.015, 0.039
0.384
0.051
Race
0.038
0.022, 0.053
<0.001
0.055
All covariates
0.005
−0.027, 0.036
0.769
0.121
All covariates except HCV
0.049
0.029, 0.069
<0.001
0.111
indicates the binary variable that distinguishes PWH from NHANES ( for PWH, for NHANES); PWH, patients with hemophilia; NHANES, subjects from the National Health and Nutrition Examination Survey of the general United States population; , regression coefficient for representing change in log SBP per unit increase of the selected covariate; CI, confidence interval; , square of the multiple correlation coefficient; BMI, body mass index; eGFR, estimated glomerular filtration rate; HCV, hepatitis C virus. Age, log BMI, eGFR, log TotalCholesterol, smoking status, HCV, and race.
