The Hypertension of Hemophilia Is Not Explained by the Usual Cardiovascular Risk Factors: Results of a Cohort Study
Table 2
Comparison of untreated (not taking antihypertensive medications) PWH and NHANES subjects.
(a)
Variable
NHANES
PWH
Median (IQR)
Median (IQR)
Systolic BP (mmHg)
118 (112–125)
1710
125 (118–134)
342
<0.001
Diastolic BP (mmHg)
72 (64–78)
1710
78 (73–83)
342
<0.001
BMI (kg/m2)
26.9 (23.7–30.5)
1703
26.1 (22.9–29.3)
323
0.016
Creatinine (mg/dL)
0.92 (0.82–1.02)
1613
0.90 (0.75–1.00)
326
<0.001
eGFR (mL/min/1.73 m2)
107 (94–119)
1613
112 (100–124)
326
<0.001
Cholesterol (total) (mg/dL)
188 (162–217)
1618
170 (146–196)
205
<0.001
(b)
Variable
NHANES
PWH
(%)
(%)
HIV
Positive
7 (0.5)
66 (20.5)
<0.001
Negative
1464 (99.5)
256 (79.5)
HCV
Positive
30 (1.9)
208 (63.8)
<0.001
Negative
1590 (98.2)
118 (36.2)
Diabetes
Positive
100 (5.9)
5 (1.5)
0.001
Negative
1610 (94.2)
336 (98.5)
Smoking
Current
473 (30.8)
42 (18.1)
<0.001
Former
300 (19.5)
37 (16.0)
Never
765 (49.7)
153 (66.0)
NHANES indicates subjects from the National Health and Nutrition Examination Survey of the general United States population; PWH, patients with hemophilia; IQR, interquartile range; BP, blood pressure; BMI, body mass index; eGFR, estimated glomerular filtration rate; and HCV, hepatitis C virus.
