Research Article
Role of Renin-Angiotensin System and Oxidative Stress on Vascular Inflammation in Insulin Resistence Model
Table 1
Metabolic and cardiovascular variables.
| Variable | WKY | FFR | SHR | FFHR | FFHR + C | FFHR + T |
| Fasting glucose (mmol/L) | 4.88 ± 0.1 | 6.44 ± 0.2* | 5.0 ± 0.2 | 6.5 ± 0.2*∧ | 5.6 ± 0.1** | 5.6 ± 0.1** | Fasting triglycerides (mmol/L) | 0.8 ± 0.0 | 1.8 ± 0.0*# | 0.9 ± 0.0 | 1.9 ± 0.1*# | 1.1 ± 0.2** | 1.7 ± 0.1 | HOMA index (U/mL insulin × mmol/L glucose)/22.5 | 4.32 ± 0.1 | 10.93 ± 0.1*# | 7.2 ± 0.1* | 14.1 ± 0.4*#∧ | 5.7 ± 0.5** | 7.2 ± 0.1 | Area under glucose tolerance test curve (mmol/L/90 min) | 881 ± 64 | 1392 ± 21*# | 1292 ± 31* | 1839 ± 51*#∧ | 971 ± 54** | 1200 ± 2.4* | HDL-Cholesterol (mg/dL) | 22.5 ± 0.7 | 12.2 ± 0.8*# | 19.3 ± 0.9* | 13.6 ± 1.2*#∧ | 19.2 ± 1.4** | 15.6 ± 2* | High-sensitivity C reactive Protein (mg/dL) | 2.55 ± 0.1 | 3.5 ± 0.0 | 3.1 ± 0.1 | 4.5 ± 0.1*#∧ | 2.01 ± 0.0** | 4.0 ± 0.0* | Systolic blood pressure (mmHg) | | | | | | | Baseline | 105 ± 3 | 102 ± 1.0 | 103 ± 1 | 105 ± 3 | 105 ± 2 | 103 ± 1 | 6 weeks | 113 ± 2.0 | 131 ± 3.0* | 161 ± 3* | 162 ± 2*# | 165 ± 2* | 165 ± 2*# | 12 weeks | 115 ± 1.3 | 136 ± 3.0* | 177 ± 1*# | 181 ± 1*#∧ | 100 ± 2.5** | 168 ± 1.1∧** |
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The above values correspond to metabolic and cardiovascular variables. Symbols indicate: * versus WKY; ∧ versus SHR; # versus FFR; **versus FFHR.
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