Research Article

Role of Renin-Angiotensin System and Oxidative Stress on Vascular Inflammation in Insulin Resistence Model

Table 1

Metabolic and cardiovascular variables.

VariableWKYFFRSHRFFHRFFHR + CFFHR + T

Fasting glucose (mmol/L)4.88 ± 0.16.44 ± 0.2*5.0 ± 0.26.5 ± 0.2*5.6 ± 0.1**5.6 ± 0.1**
Fasting triglycerides (mmol/L)0.8 ± 0.01.8 ± 0.0*#0.9 ± 0.01.9 ± 0.1*#1.1 ± 0.2**1.7 ± 0.1
HOMA index
( U/mL insulin × mmol/L glucose)/22.5
4.32 ± 0.110.93 ± 0.1*#7.2 ± 0.1*14.1 ± 0.4*#5.7 ± 0.5**7.2 ± 0.1
Area under glucose tolerance test curve
(mmol/L/90 min)
881 ± 641392 ± 21*#1292 ± 31*1839 ± 51*#971 ± 54**1200 ± 2.4*
HDL-Cholesterol (mg/dL)22.5 ± 0.712.2 ± 0.8*#19.3 ± 0.9*13.6 ± 1.2*#19.2 ± 1.4**15.6 ± 2*
High-sensitivity C reactive Protein (mg/dL)2.55 ± 0.13.5 ± 0.03.1 ± 0.14.5 ± 0.1*#2.01 ± 0.0**4.0 ± 0.0*
Systolic blood pressure (mmHg)
 Baseline105 ± 3102 ± 1.0103 ± 1105 ± 3105 ± 2103 ± 1
 6 weeks113 ± 2.0131 ± 3.0*161 ± 3*162 ± 2*#165 ± 2*165 ± 2*#
 12 weeks115 ± 1.3136 ± 3.0*177 ± 1*#181 ± 1*#100 ± 2.5**168 ± 1.1**

The above values correspond to metabolic and cardiovascular variables.
Symbols indicate: * versus WKY; versus SHR; # versus FFR; **versus FFHR.