Influence of Angiotensin II Subtype 2 Receptor (R) Antagonist, PD123319, on Cardiovascular Remodelling of Aged Spontaneously Hypertensive Rats during Chronic Angiotensin II Subtype 1 Receptor (R) Blockade
Figure 2
(a) Ventricular weight to body weight (BW) ratio and (b) left ventricular (LV) volume to body weight ratio of adult SHRs, at baseline and during treatment with vehicle (control, ), candesartan cilexetil (2 mg/kg/day) alone (), or in combination with PD123319 (10 mg/kg/day, ), and PD123319 alone (). (c) Ventricular weight to BW ratio and (d) LV volume to BW ratio of senescent SHRs, at baseline and during treatment with vehicle (control, ), candesartan cilexetil (2 mg/kg/day) alone (), or in combination with PD123319 (10 mg/kg/day, ), PD123319 alone (), or hydralazine (30 mg/kg/day, ). * versus control (1-way ANOVA).
