Differential Mechanisms of Ang (1-7)-Mediated Vasodepressor Effect in Adult and Aged Candesartan-Treated Rats

<table>Schema depicting differential mechanisms of Ang (1-7)-mediated vasodepressor effect in adult and aged candesartan-treated rats. <svg height="15.675" id="M108" style="vertical-align:-3.276pt" version="1.1" viewbox="0 0 38.125 15.675" width="38.125" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> expression was similar in aortae from adult and aged rats whereas there was upregulation of <svg height="15.675" id="M109" style="vertical-align:-3.276pt" version="1.1" viewbox="0 0 38.125 15.675" width="38.125" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>, <i>Mas</i>R, and ACE2. Therefore, a lower level of <svg height="15.675" id="M110" style="vertical-align:-3.276pt" version="1.1" viewbox="0 0 38.125 15.675" width="38.125" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,0,0,-.017,.062,11.538)"><path d="M673 0h-245v28q47 6 58 16t1 39l-55 154h-213q-31 -87 -36 -129q-16 -47 -5 -61t68 -19v-28h-226v28q50 7 68.5 23.5t43.5 80.5l214 524l24 9l193 -536q23 -63 41.5 -79.5t68.5 -21.5v-28zM418 280l-81 255h-2q-74 -197 -101 -255h184z" id="x41"></path></g><g transform="matrix(.017,0,0,-.017,10.687,11.538)"><path d="M592 498l-30 -3q-13 63 -31 89q-13 19 -33.5 25.5t-75.5 6.5h-70v-493q0 -60 16 -75.5t86 -19.5v-28h-286v28q68 4 83.5 19.5t15.5 75.5v493h-62q-60 0 -83 -7t-33 -24q-12 -17 -32 -90h-29q10 116 12 180h20q10 -16 21 -20.5t34 -4.5h395q19 0 28.5 5t21.5 20h21
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</svg> blockade with candesartan (<b>X</b>) was required in aged animals (b) compared with adult animals (a) in order to unmask the vasodilator axis. <i>Mas</i>R was not functionally active in adult rats.</table>

International Journal of Hypertension

fig6

Figure 6

Figure 6: Differential Mechanisms of Ang (1-7)-Mediated Vasodepressor Effect in Adult and Aged Candesartan-Treated Rats 