Differential Mechanisms of Ang (1-7)-Mediated Vasodepressor Effect in Adult and Aged Candesartan-Treated Rats

Figure 2

Effect of Ang (1-7) (15 pmol/kg/min; 4-hour infusion depicted by full line), AT₁R antagonist, candesartan (0.1 mg/kg bolus IV; depicted by an arrow), Ang (1-7) + candesartan, and Ang (1-7) + candesartan + AT₂R antagonist, PD123319 (50 μg/kg/min for 2 hours; depicted by dashed line), on MAP in (a) adult WKY rats (𝑛=6) and (b) aged WKY rats (𝑛=7). Values represent mean ± SEM. *𝑃<0.05; **𝑃<0.01; ***𝑃<0.001, for treatment effect of Ang (1-7) + candesartan versus all other treatments as indicated (2-way RM ANOVA).

(a)

(b)