Cholangiopathy: Genetics, Mechanism, and Pathology
1Department of Human Pathology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8640, Japan
2Division of Transplantation, Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, US
3Institute of Liver Studies, King's College Hospital, Denmark Hill, London SE5 9RS, UK
Cholangiopathy: Genetics, Mechanism, and Pathology
Description
Cholangiopathy is pathologically and pathogenetically heterogeneous and includes a broad spectrum of clinical manifestations. Recent advances in biology and medicine have introduced new technologies to study the cholangiocyte biologies and physiologies and the genetics, pathogenesis, and pathology of cholangiopathy. Several animal models have been developed for autoimmune and genetic cholangiopathy. Knowledge and understanding of these conditions have led to the development of promising therapies and novel tools to characterize these clinical conditions.
We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the pathogenesis and pathology of genetic, infectious, immune-mediated, and sclerosing cholangiopathy and the development of strategies to treat these cholangiopathies. We are particularly interested in articles describing the new approaches to the genetic and inflammatory cholangiopathy with respect to animal models and molecular immunologies; new insights into progenitor cells, autophagy, cellular senescence, regeneration, regulatory T cells, and natural killer cells; current concepts in the treatment and diagnosis of cholangiopathy using small molecules, SiRNA, molecular targets, and gene therapy strategies. Potential topics include, but are not limited to:
- Recent developments in cholangiocyte biologies
- Advances in molecular and genetic aspects of cholangiopathy
- Cholangiopathy after liver transplantation: recurrence or rejection
- Role of chemokines and cytokines in immune-mediated cholangiopathy
- Innate and acquired immunity to pediatric cholangiopathy and sclerosing cholangitis
- Cellular senescence and cholangiopathy
- Animal model of autoimmune cholangiopathy and genetic cholangiopathy
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