International Journal of Hepatology

Multiple Factors Involved in Nonalcoholic Hepatitis Pathogenesis


Publishing date
11 May 2012
Status
Published
Submission deadline
11 Nov 2011

Lead Editor

1Department of Medicine, Jewish General Hospital, McGill University, Montreal, QC, Canada

2Department of Gastroenterology, Sunnybrook Hospital, Toronto, ON, Canada

3Global Clinical, Novartis Oncology, New Jersey, NY, USA


Multiple Factors Involved in Nonalcoholic Hepatitis Pathogenesis

Description

Multiple factors are involved in pathogenesis of liver inflammation—hepatitis. Hepatitis has multiple origins as facets of the noxae that produces this inflammation. Selective recruitment and retention of certain immune populations occur during diverse liver diseases, and the immune cells play a critical role in development and resolution of liver inflammation, extracellular matrix deposition, and cell death.Nonalcoholic steatohepatitis (NASH) presents similar histopathologic picture and affects about 3 percent of the lean and 19 percent of the obese nondrinking population. Nonalcoholic, nonviral inflammation of the liver encompasses diseases with different degrees of severity, from simple steatohepatitis to cirrhosis, liver failure, or hepatocellular carcinoma. Currently the “golden standard” to diagnose the severity of hepatitis is liver biopsy. Several noninvasive procedures have been proposed. There is a lack of an adequate knowledge on the mechanism and proper noninvasive monitoring in NASH and drug-induced liver injury (DILI). This basic knowledge similarly afflicts drug development programs since it is difficult to predict which new therapeutic compounds may be effective and safe. A better understanding of predisposing genetic factors and pathophysiology, with attendant progress in diagnostic and predictive biomarkers, could be expected to reap substantial benefits for afflicted patients in the provision of optimal medical care, as well as substantial savings in healthcare costs. Knowledge of the genetic, metabolic, and immune basis of individual patients is conducive to safe and effective drug use in hepatitis. We invite investigators to contribute original research articles as well as review articles that cover these aspects of non-alcohol-induced hepatitis. Potential topics include, but are not limited to:

  • Parenchymal and nonparenchymal cells in development and progression of non-alcohol-induced liver injury
  • Role of immune system in developing hypersensitive syndrome leading to DILI
  • Genes and immune system involved in DILI and NASH
  • Mediators of inflammation pathogenesis role of immune system
  • Cytokines and chemokines in NASH and DILI
  • Nonparenchymal cells signalling for fibrosis in non-alcohol-induced liver damage
  • Laboratory assessment in NASH and DILI
  • Hepatocellular carcinoma and nonalcoholic steatohepatitis
  • Therapeutic interventions

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ijhep/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 429805
  • - Editorial

Multiple Factors Involved in Nonalcoholic Hepatitis Pathogenesis

Manuela Neuman | Nir Hilzenrat | ... | Radu Nanau
  • Special Issue
  • - Volume 2012
  • - Article ID 212865
  • - Review Article

Etiopathogenesis of Nonalcoholic Steatohepatitis: Role of Obesity, Insulin Resistance and Mechanisms of Hepatotoxicity

Praveen Guturu | Andrea Duchini
  • Special Issue
  • - Volume 2012
  • - Article ID 723062
  • - Review Article

The Link between Hypersensitivity Syndrome Reaction Development and Human Herpes Virus-6 Reactivation

Joshua C. Pritchett | Radu M. Nanau | Manuela G. Neuman
  • Special Issue
  • - Volume 2012
  • - Article ID 850836
  • - Review Article

Role of NKT Cells in the Pathogenesis of NAFLD

Kazuto Tajiri | Yukihiro Shimizu
  • Special Issue
  • - Volume 2012
  • - Article ID 925807
  • - Review Article

Nutrition and Nonalcoholic Fatty Liver Disease: The Significance of Cholesterol

Munechika Enjoji | Kenichiro Yasutake | ... | Makoto Nakamuta
  • Special Issue
  • - Volume 2012
  • - Article ID 431761
  • - Review Article

“Human Babesiosis”: An Emerging Transfusion Dilemma

Helieh S. Oz | Karin H. Westlund
  • Special Issue
  • - Volume 2012
  • - Article ID 265305
  • - Research Article

Paraoxonase Activity and Expression Is Modulated by Therapeutics in Experimental Rat Nonalcoholic Fatty Liver Disease

O. Hussein | J. Zidan | ... | M. Aviram
  • Special Issue
  • - Volume 2012
  • - Article ID 760706
  • - Review Article

HIV-Antiretroviral Therapy Induced Liver, Gastrointestinal, and Pancreatic Injury

Manuela G. Neuman | Michelle Schneider | ... | Charles Parry
International Journal of Hepatology
 Journal metrics
Acceptance rate-
Submission to final decision70 days
Acceptance to publication32 days
CiteScore2.280
Impact Factor-
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