Liver Injury Patterns and Hepatic Toxicity among People Living with and without HIV and Attending Care in Urban Uganda

Table 4

Predictors of liver injury patterns among adults with and without HIV attending outpatient care at Mulago Hospital (2015-2020).

Variable	Cholestatic liver injury			Mixed liver injury			Hepatocellular liver injury
	OR	95% CI	value	OR	95% CI	value	OR	95% CI	value
	Participants without HIV
Male gender	0.5	(0.1-1.7)	0.291	1.1	(0.3-4.0)	0.906	0.1	(0.01-1.2)	0.07
Ever used alcohol	4.9	(1.0-24.2)	0.054	5.3	(1.1-27.3)	0.043	13.2	(1.0-167.3)	0.046
Used herbs in the last 12 months	606		0.987	498		0.987	139		0.988
Total cholesterol	1.0	(0.9-1.0)	0.888	1.0	(0.9-1.0)	0.57	1.0	(0.9-1.1)	0.673
LDL-C	1.0	(0.9-1.1)	0.386	1.0	(0.9-1.1)	0.254	1.0	(0.9-1.1)	0.993
	1.0	(0.9-1.0)	0.067	1.0	(0.9-1.0)	0.353	1.0	(0.9-1.0)	0.331
	Participants with HIV
Male gender	0.6	(0.2-2.3)	0.517	2.0	(0.5-7.4)	0.299	8.7	(0.7-113.3)	0.098
Increasing age	2.3	(1.0-5.3)	0.038	1.1	(0.5-2.6)	0.775	1.1	(0.3-4.5)	0.915
cART	0.6	(0.2-2.8)	0.536	0.9	(0.2-4.2)	0.906	1.8	(0.1-25.3)	0.662
	0.7	(0.2-2.2)	0.537	1.3	(0.4-4.4)	0.659	0.8	(0.1-6.1)	0.851
Using Septrin prophylaxis			0.986			0.986	0.5		1.000

Outcome treated as multicategory and base group and/or reference group is participants with no liver injury.