Inhibition of Gluconeogenesis by Boldine in the Perfused Liver: Therapeutical Implication for Glycemic Control

Figure 3

Effects of boldine on fructose gluconeogenesis in the perfused livers isolated from fasted rats. Time courses (a) and concentration-dependent effects of boldine (b) on fructose gluconeogenesis and related parameters. Livers were perfused as described in the Materials and Methods. In (a), data are the of 4 liver perfusion experiments. Boxes near to the time scale indicate the fructose and boldine infusion periods and concentrations. In (b), the rates of pyruvate, lactate, and glucose productions and oxygen uptake were evaluated at 36 minutes of perfusion time (control condition, zero boldine concentration; ) and at 56 min perfusion time (). Asterisks () in (b) indicate those rates that differ from the control condition (absence of boldine; ).

(a)

(b)