Inhibition of Gluconeogenesis by Boldine in the Perfused Liver: Therapeutical Implication for Glycemic Control

Figure 1

The effects of boldine on glycogen catabolism in the livers from fed rats. (a) Time courses of the changes caused by 200 μM boldine. Data are the of 4 to 6 liver perfusion experiments. The time period of boldine infusion is indicated by the horizontal bar. (b) Concentration dependences of the effects of boldine on the rates of oxygen uptake, lactate and pyruvate productions, and glucose output. All parameters were evaluated before (10 minutes of perfusion time) and at 20 min after starting boldine infusion (30 minutes of perfusion time). The values corresponding to zero boldine concentration (controls) are the of 12 perfusion experiments, computed just before initiating boldine infusion; rates in the presence of boldine represent the means of 4 liver perfusion experiments computed at 30 minutes of perfusion time. Asterisks () identify those rates that differ from the control condition, as indicated by the post hoc Student-Newman-Keuls testing ().

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