International Journal of Hepatology

Research Article

Spleen and Liver Stiffness Evaluation by ARFI Imaging: A Reliable Tool for a Short-Term Monitoring of Portal Hypertension?

Table 2

HVPG, LSM, and SSM results according to initiated NSBB treatment (NSBB = non-selective beta-blocker; HVPG = hepatic venous pressure gradient; LSM = Liver stiffness measurement; SSM = spleen stiffness measurement). All the values are presented as median values (min–max).


	HVPG (mmHg)	LSM (m/s)	SSM (m/s) upper	SSM (m/s) hilar	SSM (m/s) bottom	SSM (m/s) overall

All patients
Baseline	18 (10-27)	2.88 (1.31–3.76)	2.55 (0.74–3.39)	2.98 (2.05–4.11)	3.59 (2.8–5.0)	3.00 (2.27–3.59)
Follow-up	17 (2–22.0)	2.89 (1.22–3.64)	2.44 (0.84–3.66)	3.21 (2.20–3.95)	3.58 (2.23–3.98)	3.03 (2.33–3.55)
Delta (value)	-1	0.01	-0.11	0.23	-0.01	0.03
Delta (% baseline)	-5.5%	0%	-4%	7%	0%	0%
Correlation with HVPG results (-value)
Baseline		0.46 ( =0.0089)	0.25 ( =0.17)	-0.12 ( =0.51)	0.086 ( =0.64)	-0.21 ( =0.239)
Follow-up		0.54 ( =0.0016)	0.1 ( =0.59)	0.001 ( =0.97)	0.13 ( =0.47)	0.12 ( =0.49)
Delta		0.16 ( =0.381)	-0.25 ( =0.17)	-0.38 ( =0.03)	0.06 ( =0.77)	-0.298 ( =0.114)

Responder
Baseline	20 (10-27)	2.85 (1.31–3.34)	2.42 (0.74–3.39)	2.54 (2.41–3.42)	3.53 (2.8–4.15)	2.96 (2.27–3.34)
Follow-up	15.5 (2–20)	2.83 (1.22–3.28)	2.42 (1.47–3.66)	3.11 (2.26–3.69)	3.44 (2.23–3.98)	3.02 (2.33–3.22)
Delta (value)	-4.5	-0.02	0	0.57	0.09	+0.06
Delta (% baseline)	-29%	- 0%	0%	22%	-3%	+ 2%
Correlation with HVPG results (-value)
Baseline		0.82 ( = 0.0003)	0.27 ( = 0.33)	- 0.17 ( = 0.53)	0.11 ( = 0.69)	- 0.33 ( = 0.25)
Follow-up		0.73 ( = 0.0026)	0.41 ( = 0.14)	0.09 ( = 0.75)	-0.04 ( = 0.88)	0.28 ( = 0.32)
Delta		0.40 ( = 0.149)	- 0.15 ( = 0.58)	- 0.27 ( = 0.34)	0.01 ( =0.94)	- 0.27 ( = 0.34)

Non-responder
Baseline	16 (12-21)	2.88 (2.09–3.76)	2.7 (1.47–3.31)	3.4 (2.05–4.11)	2.7 (1.47–3.32)	3.23 (2.38–3.59)
Follow-up	19 (14–22)	3.09 (1.72–3,64)	2.46 (0.84–3.27)	3.24 (2.2–3.95)	2.46 (0.84–3.27)	3.03 (2.41–3.55)
Delta (value)	3	0.21	- 0.24	- 0,16	-0,24	- 0.2
Delta (% baseline)	16%	7%	- 9%	- 5%	9%	- 7%
Correlation with HVPG results
Baseline		0.07 ( = 0.76)	- 0,18 ( = 0.48)	0.13 ( =0.59)	0.13 ( = 0.6)	0.06 ( = 0.82)
Follow-up		-0.01 ( =0.96)	- 0.26 ( = 0.31)	-0.21 ( = 0.31)	0.25 ( = 0.32)	- 0.17 ( = 0.50)
Delta		- 0.26 ( = 0.31)	- 0.49 ( = 0.04)	0.21 ( = 0.4)	0.34 ( =0.17)	0.04 ( = 0.85)