Comparative Study of Protective Effect of Cimetidine and Verapamil on Paracetamol-Induced Hepatotoxicity in Mice

Figure 4

Biochemical and histological analysis of group 4. (a) ALT, ALP and AST serum content in group 4 (PCM/Cimetidine group). Mice were given 300 mg per kg of paracetamol and 150 mg per kg Cimetidine via intraperitoneal injection for two weeks. X-axis represents the mice while Y-axis shows the serum content of liver function enzymes. (b) Bilirubin content of group 4 mice after two weeks treated with 300 mg/kg paracetamol plus 150 mg/kg Cimetidine. Y-axis shows the serum level of Bilirubin (mg/dl) while X-axis represents the number of mice. (c) Histological examination of liver tissues of PMC/Cimetidine group. After treatment with 300 mg/kg paracetamol and 150 mg/kg Cimetidine for two weeks, liver tissues with fixed with 10% formaldehyde, and proceed with H & E staining as described in Section 2.

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