International Journal of Hepatology / 2019 / Article / Tab 4 / Research Article
Preoperative Neutrophil-to-Lymphocyte Ratio Plus Platelet-to-Lymphocyte Ratio Predicts the Outcomes after Curative Resection for Hepatocellular Carcinoma Table 4 Clinicopathological characteristics of patients undergoing curative hepatectomy for HCC.
Clinical variables NLR-PLR 0 NLR-PLR 1 NLR-PLR 2 p n = 64 (49%) n = 32 (24%) n = 36 (27%) Patient factors Male (n, %) 55 (85.9%) 29 (90.6%) 32 (88.9%) 0.78 Age(years; mean ± SD) 64.5±8.9 67.8±8.8 63.9±12.6 0.24 Hepatitis B (n, %) 39 (60.9.%) 18 (56.2%) 18 (50.0%) 0.57 Child-Pugh Class B (n, %) 1 (1.6) 3 (9.4%) 9 (25.0%) <0.01 Laboratory data ICG>15 (n, %) 21 (32.8%) 7 (21.9%) 2 (5.6%) 0.01 Creatinine (mean ± SD) 104±133 95±43 87±101 0.69 Surgical factors Major hepatectomy (n, %) 26 (40.6%) 12 (37.5%) 23 (63.9%) 0.04 Operation time >350min (n, %) 21 (32.8%) 7 (21.9%) 15 (41.7%) 0.22 EBL >500ml (n, %) 37 (57.8%) 19(59.4%) 25 (69.4%) 0.50 Tumor factors AFP >400ug/L (n, %) 11 (20.8%) 6 (18.8%) 1 (2.7%) 0.08 Tumor size >5 (n, %) 20 (31.2%) 12 (37.5%) 28(77.8%) <0.01 Multiple tumors (n, %) 12 (18.8%) 10 (31.2%) 8 (22.2%) 0.38 R1 resection (n, %) 4 (6.2%) 2 (6.2%) 7 (19.4%) 0.08 Postoperative factors Wound infection 2 (3.1%) 3 (9.4%) 1 (2.8%) 0.32 Pneumonia 10 (15.6%) 5 (15.6%) 7 (19.4%) 0.87 UTI 3 (4.7%) 3 (9.4%) 1 (2.8%) 0.46 Bile leak 0 (0) 0 (0) 2 (5.6%) 0.07 Intra-abdominal collection 2 (3.1%) 0 (0) 2 (5.6%) 0.41 Liver failure 4 (6.2%) 3 (9.4%) 4 (11.1%) 0.68 Follow-up 30-day mortality 2 (3.1%) 1 (3.1%) 0 (0) 0.52 LOS (days, mean ± SD) 11.2±11.6 13.4±20.6 19.7± 26.2 0.22 OS (months, median [IQR]) 26.5 (11-48) 19.5 (5-36) 24.5 (7-37) 0.02 RFS (months, median [IQR]) 20 (7-40.5) 12 (5-25) 14.5 (4-28) 0.02
NLR: neutrophil-to-lymphocyte ratio; PLR: platelet-to-lymphocyte ratio; ICG: indocyanine green; EBL: estimated blood loss; AFP: a-fetoprotein; UTI: urinary tract infection; LOS: length of stay; OS: overall survival; RFS: recurrence free survival; IQR: interquartile range; SD: standard derivation.