Relationship between Serum Cytokeratin-18, Control Attenuation Parameter, NAFLD Fibrosis Score, and Liver Steatosis in Nonalcoholic Fatty Liver Disease

Table 4

Relationship between inflammatory markers, CK-18, fibroscan findings, and liver steatosis grade as assessed by US. Me, Median; : Spearmancoefficient correlation; : significant. ALT: alanine transaminase; AST: aspartate transaminase; CRP: C-reactive protein; CK-18: cytokeratin-18; CAP: controlled attenuated parameter; LSM: liver stiffness measurement.

	Non hepatic-steatosis; Me(IQR)	Hepatic Steatosis Grade			p value
		S1; Me(IQR)	S2; Me(IQR)	S3; Me(IQR)
ALT, U/L	18.5(14-27.5)	31(21.75-65)	56(31-76)	68(31-112)	<0.001	0.54
AST, U/L	20.5(17-24.5)	22.5(21-34.5)	28(24-47.5)	45(34.5-48.5)	<0.001	0.53
CRP, mg/dL	0.08(0.05-0.2)	0.23(0.06-0.45)	0.27(0.09-0.73)	0.33(0.08-0.43)	0.462	0.25
CK-18, U/L	91(70-104)	189.5(137-227.5)	277(189.5-326)	441(338-554.5)	<0.001	0.68
CAP, dB/m	234(95-266)	310(277-330)	331(279-364)	334(323-374)	<0.001	0.56
LSM, kPa	5.3(3.9-5.9)	6.5(5.4-9.9)	9.3(7-11.5)	8.4(6.9-11.5)	0.001	0.49