Comparative Protective Effects of N-Acetylcysteine, N-Acetyl Methionine, and N-Acetyl Glucosamine against Paracetamol and Phenacetin Therapeutic Doses–Induced Hepatotoxicity in Rats
Table 1
Mean ± SD of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) levels, AFP, and 8-OH-Gua among the studied groups.
Animal groups
N
ALT (U/L)
AST (U/L)
AFP(ng/ml)
8-OH-Gua(mg/l)
Controls
10
81.45 ± 37.8
100.2 ± 27.84
12.23 ± 0.4265
2.240 ± 1.072
Paracetamol groups
PA
10
124.9 ± 38.2
150.5 ± 50.7
12.58 ± 0.617
3.643 ± 1.01
PA+NAC
10
73.11 ± 17.0
66.93 ± 32.6
12.45 ± 0.271
0.8158 ± 0.360
PA+NAM
10
63.34 ± 10.0
53.34 ± 14.2
12.43 ± 0.428
1.981 ± 0.305
PA+NAG
10
60.58 ± 12.2
55.38 ± 15.2
12.50 ± 0.298
1.097 ± 0.244
Phenacetin groups
PH
10
127.1 ± 2
150.7 ± 57.5
12.74 ± 0.622
4.643 ± 1.03
PH+NAC
10
55.46 ± 17.7
76.82 ± 26.6
12.22 ± 0.399
1.535 ± 0.121
PH+NAM
10
52.85 ± 13.2
60.57 ± 7.7
12.03 ± 0.609
1.892 ± 0.772
PH+NAG
10
54.46 ± 14.3
59.00 ± 14.2
12.28 ± 0.277
1.026 ± 0.432
p<0.05, p<0.01, p<0.001; ns: nonsignificant (p>0.05); a: comparison with control group, b: comparison with the drug only (PA or PH) group. PA: paracetamol; PH: phenacetin; NAC: N-acetyl cysteine; NAM: N-acetyl methionine; NAG: N-acetyl glucosamine; AFP: alpha fetoprotein; 8-OH-Gua: 8-hydroxyguanine.
