Comparative Protective Effects of N-Acetylcysteine, N-Acetyl Methionine, and N-Acetyl Glucosamine against Paracetamol and Phenacetin Therapeutic Doses–Induced Hepatotoxicity in Rats

Figure 4

Histological changes in the rats' liver of various phenacetin groups. (a) Photomicrograph of a section in the liver of group VI showing dilated central vein with many cells in the lumen (C). (b) Group VI showing large irregular area of disturbed liver architecture (arrow). (c) Group VII showing minimal cellular infiltration (arrow) with dilated congested central veins (C). (d) Group VIII showing a localized area of disturbed architecture that contains many cells with vacuolated cytoplasm (arrow). (e) Group IX showing area of cellular infiltration (arrow) and the other area showing degenerated hepatocytes with many spaces (arrow head). Notice the dilated blood sinusoids with some cells in the lumen(). (f) Group IX showing dilated blood sinusoids (S). H&E x400.

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