Development of NASH in Obese Mice is Confounded by Adipose Tissue Increase in Inflammatory NOV and Oxidative Stress

Figure 7

Adipose tissue HO-1 upregulation increases anti-inflammatory adiponectin and mitochondrial fusion-associated proteins, while decreasing proinflammatory NOV and the mitochondrial fission-associated protein, FIS1. (a) Representative western blots, and densitometry analysis of (b) NOV, (c) MFN1, (d) MFN2, (e) FIS1, and (f) adiponectin. (g) HO-1 mRNA levels in NOV overexpressing 3T3-L1 derived adipocytes. Results are mean ± SE, n=4, p<0.05 versus lean mice/control, p<0.05 versus HF fed mice, and p<0.05 versus HF fed mice + CoPP.

(a)

(b)

(c)

(d)

(e)

(f)

(g)