Development of NASH in Obese Mice is Confounded by Adipose Tissue Increase in Inflammatory NOV and Oxidative Stress

Figure 5

HO-1 upregulation increases hepatic pAKT, pAMPK, and insulin receptor phosphorylation levels. Representative western blots (a) and densitometry analysis of (b) IRp972, (c) IRp1146, and (d) SIRT1 in hepatic tissues of control lean mice, HF fed mice, HF fed mice + CoPP, and HF fed mice + CoPP + SnMP. Results are mean ± SE, n=4, p<0.05 versus lean mice, p<0.05 versus HF fed mice, and p<0.05 versus HF fed mice + CoPP.

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