Development of NASH in Obese Mice is Confounded by Adipose Tissue Increase in Inflammatory NOV and Oxidative Stress

Figure 2

Induction of HO-1 decreases NOV and fibrotic markers and improves ALT and AST. (a) The mRNA expression of NOV, (b) representative western blots and densitometry analysis of (c) NOV, (d) FAS, and (e) MMP2 and levels of (f) AST(U/L), and (g) ALT(U/L) in hepatic tissues of control lean mice, HF fed mice, HF fed + with CoPP, and HF fed mice + CoPP + SnMP. (h) NOV mRNA levels in visceral adipose tissue (VAT) and liver of lean mice. Results are mean ± SE, n=6, p<0.05 versus lean mice, p<0.05 versus HF fed mice, and p<0.05 versus HF fed mice + CoPP.

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