Development of NASH in Obese Mice is Confounded by Adipose Tissue Increase in Inflammatory NOV and Oxidative Stress

Figure 1

HO-1 induction prevents fibrosis and decreases NASH score. Liver of lean (a), HF fed (b), HF fed treated with CoPP (c), and HF fed treated with CoPP and SnMP (d) in mice and (e) graph summarizes the morphometrical analysis of liver lipid droplet diameter. p< 0.05 versus lean; p< 0.05 versus HF fed; and + p< 0.05 versus HF fed mice + CoPP. Masson’s trichrome staining. Bar 20 μm. The arrow shows hepatic perivascular fibrosis and () indicates the steatosis of control lean mice, HF fed mice, HF fed mice + CoPP, and HF fed mice + CoPP + SnMP.

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