Evaluation of Serum Cystatin C as a Marker of Early Renal Impairment in Patients with Liver Cirrhosis

Table 5

Area under the curve for detecting early renal impairment for studied tests and formulae.

Variable	AUC	95% CI
1/Cr	0.642	0.500–0.784	0.058
CCr	0.674	0.533–0.815	0.020
1/CysC	0.785	0.663–0.907	<0.0001
MDRD 4	0.646	0.506–0.787	0.051
MDRD 6	0.644	0.503–0.784	0.054
C-G formula	0.562	0.413–0.710	0.411
CKD-EPI-Cr	0.632	0.491–0.773	0.078
CKD-EPI-CysC	0.788	0.667–0.909	<0.0001
CKD-EPI-Cr-CysC	0.808	0.695–0.921	<0.0001

AUC, area under the curve; C-G formula, Cockcroft-Gault formula; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; CI, confidence interval; Cr, creatinine; CCr, creatinine clearance; CysC, cystatin C; MDRD, modification of diet in renal disease equation with 4 and 6 variables.