Oxidative Stress and Inflammation: Essential Partners in Alcoholic Liver Disease

Figure 1

Oxidative stress and inflammation: interacting mechanisms in ALD. The development of alcoholic liver injury is a complex process involving oxidative stress microenvironment in the liver contributed by hepatocytes and macrophages. In addition to the activation of macrophages by gut-derived endotoxin, cellular stress responses contribute to proinflammatory cytokine production creating a tightly interrelated network in ALD.