PBC: Animal Models of Cholangiopathies and Possible Endogenous Viral Infections
Table 2
Antiviral trials for PBC.
Trial
Method
Subject
Design
Primary outcome
Year
Reference
Pilot studies of single and combination antiretroviral therapy
Lamivudine + Zidovu- dine versus Lamivudine
Human
Randomized controlled trial (RCT)
Serological improvements of alkaline phos-phatase, AST and ALT. Histological improvement in necroinflammatory score and a reduction in bile duct injury.