Analysis of Extrahepatic Multiple Primary Malignancies in Patients with Hepatocellular Carcinoma according to Viral Infection Status

Table 4

Odds ratios for infection-associated EHPM^† according to viral infection status.

	Infection-associated EHPM (+)	Infection-associated EHPM (−)	Odds ratio (95% CI)	𝑃 value
HCV Ab (+)	27	240	3.15 (1.19–8.37)	0.0194
HCV Ab (−)	5	140
HBs Ag (+)	4	61	11.31 (2.03–63.11)	0.0067
HBs Ag (−)	2	345
No viral infection	4	67	20.30 (2.23–184.46)	0.0036
Any viral infection	1	340

^†Gastric cancer for the presence or absence of HCV Ab, urinary tract cancer for the presence or absence of HBs Ag, breast cancer for both HCV Ab- and HBs Ag-negative or either HCV Ab- or HBs Ag-positive.
EHPM: Extrahepatic primary malignancy, HBs Ag: Hepatitis B virus surface antigen, HCV Ab: Hepatitis C virus antibody, CI: Confidence interval.