Review Article
Pathological Features of New Animal Models for Primary Biliary Cirrhosis
Table 4
Comparison of novel PBC animal models.
| | Spontaneous models |
Xenobiotic-immunized induced model | | NOD.c3c4 mice | dnTGF-βRII mice | IL-2 Rα −/− mice | Scurfy mice | mice | 6-BH-immunized guinea pigs | 2-OA-immunized mice |
| Advantages | | | | | | | | AMA | 50–60% | 100% | 100% | 100% | 40–80% | 100% | 100% | Dominant AMA target protein | PDC-E2 | PDC-E2 | PDC-E2 | PDC-E2 | PDC-E2 | PDC-E2 | PDC-E2 | Biliary damage | + | ++ | +−++ | +−++ | +−+++ | + | +−++ | Granuloma | + | + | − or + | − | ? | ++ | ++ | Pro-inflammatory cytokines | + | + | + | + | + | + | + |
| Disadvantages | Biliary dilatation | moderate colitis | Severe colitis Severe hemolytic anemia | Short lifespan | Late onset | Late onset | peritonitis |
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