Non-Invasive Radiofrequency-Induced Targeted Hyperthermia for the Treatment of Hepatocellular Carcinoma

Figure 1

Principle of the non-invasive RF based treatment of HCC. A. RF field source is used to generate a uniform low frequency electromagnetic field that penetrates tissues and reaches the tumor. B. Nanoparticles that can be thermally activated are conjugated to monoclonal antibodies against known targets expressed on HCC (i), internalized specifically by cancer cells after systemic administration (ii), and upon RF activation release heat (iii) causing targeted cancer cell death.