Review Article

Indications and Contraindications for Liver Transplantation

Table 1

United network for organ-sharing (UNOS) liver status classification.

Status 1Fulminant liver failure with life expectancy <7 days
(i) Fulminant hepatic failure as traditionally defined
(ii) Primary graft nonfunction <7 days of transplantation
(iii) Hepatic artery thrombosis <7 days of transplantation
(iv) Acute decompensated Wilson’s disease

Status 2aHospitalized in ICU for chronic liver failure with life expectancy <7 days, with a Child-Pugh score of ≥10 and one of the following:
(i) unresponsive active variceal hemorrhage
(ii) hepatorenal syndrome
(iii) refractory ascites/hepatic hydrothorax,
(iv) Stage 3 or 4 hepatic encephalopathy

Status 2BRequiring continuous medical care, with a Child-Pugh score of ≥10, or a Child-Pugh score ≥7 and one of the following:
(i) unresponsive active variceal hemorrhage
(ii) hepatorenal syndrome
(iii) spontaneous bacterial peritonitis
(iv) refractory ascites/hepatic hydrothorax,
or presence of hepatocellular carcinoma

Status 3Requiring continuous medical care, with a Child-Pugh score of ≥7, but not meeting criteria for Status 2B

Status 7Temporary inactive

From http://www.unos.org/ initially implemented in July 1997 later modified in January 1998 and August 1998.