TY - JOUR A2 - Guan, Richard AU - Varma, Vibha AU - Mehta, Naimish AU - Kumaran, Vinay AU - Nundy, Samiran PY - 2011 DA - 2011/10/05 TI - Indications and Contraindications for Liver Transplantation SP - 121862 VL - 2011 AB - Patients with chronic liver disease and certain patients with acute liver failure require liver transplantation as a life-saving measure. Liver transplantation has undergone major improvements, with better selection of candidates for transplantation and allocation of scarce deceased donor organs (according to more objective criteria). Living donor liver transplantation came into existence to overcome the shortage of donor organs especially in countries where there was virtually no deceased donor programme. Advances in the technical aspects of the procedure, the intraoperative and postoperative care of both recipients and donors, coupled with the introduction of better immunosuppression protocols, have led to graft and patient survivals of over 90% in most high volume centres. Controversial areas like transplantation in alcoholic liver disease without abstinence, acute alcoholic hepatitis, and retransplantation for recurrent hepatitis C virus infection require continuing discussion. SN - 2090-3448 UR - https://doi.org/10.4061/2011/121862 DO - 10.4061/2011/121862 JF - International Journal of Hepatology PB - SAGE-Hindawi Access to Research KW - ER -