Two Variants in the NOTCH4 and HLA-C Genes Contribute to Familial Clustering of Psoriasis

Table 4

Association of human leukocyte antigen (HLA) with a family history of psoriasis.

Variants	Frequency		PFH vs. SP
	Freq_PFH	Freq_SP	OR (95% CI)	value
HLA-C06:02^1	0.479	0.444	1.33 (1.17–1.52)
HLA-C07:04	0.015	0.015	0.92 (0.65–1.29)	0.624
HLA-C01:02	0.092	0.107	0.93 (0.80–1.07)	0.295
B-Y67C	0.081	0.092	0.86 (0.74–0.998)	0.047
B-Y116S	0.313	0.316	1.01 (0.92–1.1)	0.920
B-Q70K	0.016	0.016	1.03 (0.74–1.44)	0.855
DPB105:01	0.354	0.362	0.98 (0.89–1.07)	0.591
A-I95V	0.250	0.257	0.95 (0.86–1.05)	0.287
NOTCH4:G511S^1	0.092	0.076	1.24 (1.07–1.44)
BTNL2:R281K^1	0.044	0.059	0.74 (0.61–0.89)
TAP201:03	0.028	0.026	1.04 (0.81–1.35)	0.76

¹Variants with in the significant threshold in case-case analysis and are marked in italics.