Two Variants in the NOTCH4 and HLA-C Genes Contribute to Familial Clustering of Psoriasis

Table 3

Association of variants with sporadic psoriasis (SP) in the multivariate regression model.

Variants	Frequency		SP vs. control
	Freq_SP^1	Freq_Control^2	OR (95% CI)	value
HLA-C alleles
HLA-C06:02	0.444	0.110	15.16 (13.93–16.49)
HLA-C07:04	0.0148	0.010	3.89 (3.04–4.99)
HLA-C01:02	0.107	0.139	1.29 (1.18–1.42)
HLA-B alleles
B-Y67C	0.093	0.087	2.26 (2.03–2.53)
B-Y116S	0.316	0.326	1.38 (1.29–1.48)
B-Q70K	0.016	0.023	0.46 (0.36–0.59)
HLA-DPB1 alleles
DPB105:01	0.362	0.364	1.29 (1.21–1.38)
HLA-A alleles
A-I95V	0.257	0.299	1.27 (1.18–1.37)
BTNL2
BTNL2:R281K	0.059	0.063	1.46 (1.29–1.66)

¹Freq_SP: the allele frequency in patients with SP. ²Freq_Control: the allele frequency in healthy controls.