MicroRNA in Glioblastoma: An Overview

Table 1

Molecular characteristics of glioblastoma subtypes according to methylation, expression, mutation, copy number variations patterns, and clinical outcome.

IDH1/IDH2 status	Wild type			Mutated
MGMT	Mostly unmethylated			Methylated
Methylation status	CIMP−			CIMP+
Mutations	TERT			ATRX-TP53	CIC-FUBP1
CNV	EGFR+	NF1−		PDGFRA+	PDGFRA+; 1p19q−
Molecular subtype	Classical	Mesenchymal	Neural	Proneural
Outcome	Very poor outcome			Significantly improved outcome	Significantly improved outcome. Better response to TMZ than 1p19q+