Genetic Background Modulates lncRNA-Coordinated Tissue Response to Low Dose Ionizing Radiation

Figure 1

Significant strain differences in lncRNA and coding RNA expression in mammary tissues of BALB/c and SPRET/EiJ mice. (a)-(b) Hierarchical clustering of baseline differences in lncRNA (a) and coding RNA (b) expression in mammary gland tissues of 8-9-week-old BALB/c and SPRET/EiJ mice (fold-change 1.5; value < 0.001). Increased expression indicated in red and decreased expression in green. (c) Gene interaction networks of genes expressed at lower levels in BALB/c mammary tissues when compared to SPRET/EiJ (top) and genes expressed at higher levels in BALB/c compared to SPRET/EiJ (bottom) (see Figure S3 for annotation of molecular shapes used in the networks).

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