An Exon-Based Comparative Variant Analysis Pipeline to Study the Scale and Role of Frameshift and Nonsense Mutation in the Human-Chimpanzee Divergence

Figure 1

The species tree-based analysis procedure is to define occurrence patterns of the exon-disrupting mutations. The tree is drawn roughly based on a phylogenetic analysis of data from eight completely sequenced nuclear genomes [41]. Abbreviations of eight mammalian species are listed as followings: HS = Homo sapiens, PT = Pan troglodytes, RM = Rhesus macaques, BT = Bos taurus, CF = Canis familiaris, MD = Monodelphis domestica, MM = Mus musculus, and RN = Rattus norvegicus. Colored lines represent different lineages: the red for human-chimpanzee-macaque lineage; the green for dogs and cows; the blue for mouse-rat.