Protein Interactions from Complexes: A Structural Perspective

Hakes, Luke; Robertson, David L.; Oliver, Stephen G.; Lovell, Simon C.

doi:https://doi.org/10.1155/2007/49356

International Journal of Genomics

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Research Article | Open Access

Volume 2007 | Article ID 049356 | https://doi.org/10.1155/2007/49356

Protein Interactions from Complexes: A Structural Perspective

Luke Hakes,¹David L. Robertson,¹Stephen G. Oliver,¹and Simon C. Lovell¹

Academic Editor: Pierre Legrain

Received17 Jun 2006

Revised28 Sept 2006

Accepted09 Oct 2006

Published19 Dec 2006

Abstract

By combining crystallographic information with protein-interaction data obtained through traditional experimental means, this paper determines the most appropriate method for generating protein-interaction networks that incorporate data derived from protein complexes. We propose that a combined method should be considered; in which complexes composed of five chains or less are decomposed using the matrix model, whereas the spoke model is used to derive pairwise interactions for those with six chains or more. The results presented here should improve the accuracy and relevance of studies investigating the topology of protein-interaction networks.

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Copyright

Copyright © 2007 Luke Hakes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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