Research article | Open Access
In Silico Analysis for Transcription Factors With Binuclear Cluster DNA-Binding Domains in Candida albicans
A total of 6047 open reading frames in the Candida albicans genome were screened for -type zinc cluster proteins (or binuclear cluster proteins) involved in DNA recognition. These fungal proteins are transcription regulators of genes involved in a wide range of cellular processes, including metabolism of different compounds such as sugars or amino acids, as well as multi-drug resistance, control of meiosis, cell wall architecture, etc. The selection criteria used in the sequence analysis were the presence of the motif and a putative nuclear localization signal. Using this approach, 70 putative transcription factors have been found in the genome of C. albicans.
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