Osteoporosis, a major worldwide public health issue, is characterized by a progressive loss of bone mineral density, disruption of bone microarchitecture, and an increased risk of fractures. Osteoporosis-related fracture causes disability, mortality, and significant financial burden. In recent years, there have been significant advances in our knowledge in bone cell biology, bone metabolism, genetics and pathogenesis of osteoporosis, evaluation of fracture risk of osteoporotic patients, and management of osteoporosis. The purpose of this special issue is to report recent advances both in basic studies and clinical research on osteoporosis.

We invite researchers to contribute original research articles as well as review articles that report new information on the etiology, pathogenesis, epidemiology, management, and long-term followup of patients suffering from osteoporosis.

Potential topics include, but are not limited to:

• Mechanism involved in regulating proliferation, differentiation, and function of osteoblasts, osteocytes, and osteoclasts
• Roles of reproductive hormones and ageing in osteoporosis
• Etiology and pathogenesis of osteoporosis
• Advances in genetics of osteoporosis
• Epidemiology of osteoporosis
• Evaluation of fracture risks using FRAX score
• Advances in management and novel pharmacologic approaches of osteoporosis