Relationship between Serum Indoxyl Sulfate and Klotho Protein and Vascular Calcification in Patients with Chronic Kidney Disease Stages 3–5
Table 2
Comparison of age, IS, and Klotho protein among groups.
Group
Healthy control (20 cases)
CKD stages 3-4 (36 cases)
CKD stage 5 nondialysis (38 cases)
CKD stage 5 dialysis (34 cases)
F/H
P value
Age (years)
49.50 ± 12.31
57.03 ± 13.08
55.45 ± 14.69
54.35 ± 12.80
1.412
0.242
IS (pg/mL)
60.72 (53.94, 64.74)abc
120.06 (90.53, 222.45)ab
345.60 (269.10, 438.05)a
731.49 (562.47, 803.55)
98.49
0.000
Klotho (ng/mL)
1.30 (1.04, 1.37)abc
0.91 (0.58, 1.20)ab
0.59 (0.45, 0.82)a
0.42 (0.36, 0.52)
70.48
0.000
aCompared with CKD stage 5 dialysis group ;bcompared with CKD stage 5 nondialysis group ;ccompared with CKD stages 3-4 dialysis group . IS, indoxyl sulfate; CKD, chronic kidney disease.
