Whether Detection of Gene Mutations Could Identify Low- or High-Risk Papillary Thyroid Microcarcinoma? Data from 393 Cases Using the Next-Generation Sequencing

Table 3

The clinicopathological characteristics of PTC patients simultaneously carried two gene mutations (fusions).

No.

Genetic alteration

Gender

Age (years)

Size (mm)

CLT

Bilateralism

Multifocality

ITS

ETE

Lymph node metastases

Tumor recurrence

Total

Central compartment

Laterocervical compartment

1

BRAF^V600E NRASQ^61R

M

48

13

No

No

Yes

No

No

0/28

0/8

0/20

No

2

BRAF^V600E NRASQ^61R

F

64

6

No

No

No

No

No

0/8

0/8

—

No

3

BRAF^V600E RET/PTC1

M

70

10

No

No

No

No

No

0/8

0/8

—

No

4

BRAF^V600E RET/PTC3

M

61

5

No

No

No

No

No

2/14

2/14

—

No

5

BRAF^V600E RET/PTC3

F

63

5

No

No

No

Yes

No

4/31

2/8

2/23

No

6

BRAF^V600E TERT promoter

M

84

13

No

No

No

No

No

0/7

0/7

—

No

CLT: chronic lymphocytic thyroiditis; ITS: intrathyroid spread; ETE: extrathyroidal extension.