Machine Learning for Predicting Distant Metastasis of Medullary Thyroid Carcinoma Using the SEER Database

Table 2

Univariable analysis and multivariable analysis of variables related to distant metastasis.

	Univariable analysis			Multivariable analysis
	OR	95% CI	value	OR	95% CI	value
Age (year)
<55	0.513	0.357–0.513	<0.001	0.480	0.323–0.713	<0.001
≥55	Ref			Ref
Gender
Female	0.377	0.263–0.540	<0.001	0.664	0.450–0.980	0.039
Male	Ref			Ref
Race
White	1.191	0.569–2.491	0.642
Black	1.464	0.596–3.596	0.406
Other	Ref
Spanish-Hispanic
Yes	Ref
No	1.268	0.752–2.139	0.373
MTC subtypes
MTC with amyloid stroma	0.774	0.278–2.150	0.623
MTC NOS	Ref
Multifocality
Solitary tumor	0.623	0.435–0.892	0.010	0.866	0.578–1.298	0.486
Multifocal tumor	Ref			Ref
Tumor size (cm)
≤2	0.116	0.073–0.185	<0.001	0.287	0.173–0.476	<0.001
2–4	0.342	0.229–0.512	<0.001	0.555	0.360−0.0855	0.008
≥4	Ref			Ref
Extrathyroidal extension
Yes	Ref			Ref
No	0.136	0.095–0.195	<0.001	0.364	0.240–0.554	<0.001
LNM
No	0.144	0.062–0.335	<0.001	0.327	0.132–0.806	0.015
Cervical central lymph node	0.906	0.401–2.050	0.813	1.021	0.437–2.385	0.962
Cervical lateral lymph node	1.414	0.647–3.091	0.386	1.269	0.564–2.858	0.565
Yes NOS	Ref			Ref

MTC, medullary thyroid carcinoma; NOS, not otherwise specified; OR, odds ratio; CI, confidence interval.