Bone Turnover Markers in Adults with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis

Table 1

Characteristics of the included studies in the meta-analysis.

Nos.	First authors	Years	Region	Population	Age (mean, SD)	Gender (male, female)	Outcomes	Quality assessment
1	Huang [16]	2021	China	90	38.86 ± 6.83	46, 44	PINP CTX	7
2	Qu [17]	2021	China	360	55.65 ± 9.13	191, 169	PINP CTX OC	7
3	Zhang [18]	2015	China	800	54.10 ± 4.47	0, 800	OC	7
4	Xin [19]	2019	China	88	40.88 ± 5.54	38, 50	OC	7
5	Du [20]	2015	China	174	66.89 ± 10.18	123, 51	OC	6
6	Cui [21]	2013	China	224	59.55 ± 5.73	99, 125	OC CTX	7
7	Hu [22]	2016	China	368	40.11 ± 10.18	273, 95	OC	7
8	Liu [23]	2013	China	1683	37.52 ± 11.23	1683, 0	OC	7
9	Dou [24]	2013	China	1558	54.02 ± 8.67	1558, 0	OC	8
10	Luo [25]	2015	China	733	56.24 ± 4.51	0, 733	OC	7
11	Deng [26]	2018	China	540	50.42 ± 5.05	540, 0	PINP CTX OC	6
12	Gudowska-Sawczuk [27]	2017	Poland	58	26–88	30, 28	PINP	5
13	Lee [28]	2018	Korea	3737	54.48 ± 2.50	0, 3737	CTX, OC	6
14	Yang [29]	2015	Korea	859	45.00 ± 6.72	859, 0	OC	8
15	Al-Akabi [30]	2021	Iraq	800	30–50	800, 0	OC	5
16	Yilmaz [31]	2011	Turkey	174	48 ± 7.56	87, 87	OC	7
17	Polyzos [32]	2015	Japan	47	53.03 ± 2.46	34, 13	CTX	6
18	Maagensen [33]	2018	Denmark	17	52.97 ± 16.93	17, 0	PINP CTX OC	6

PINP, procollagen type I N-terminal propeptide; CTX, C-terminal cross-linked telopeptide; OC, osteocalcin.