Research Article
GLP1R rs3765467 Polymorphism Is Associated with the Risk of Early Onset Type 2 Diabetes
Table 6
Comparison of clinical characteristics according to rs3765467 genotype after subgrouping the LOD group.
| | Parameters | GG | GA + AA | |
| | Subjects (n) | 105 | 74 | — | | Sex (M/F) | 42/63 | 31/43 | 0.800 | | Age (years) | 60.1 ± 7.0 | 60.5 ± 6.7 | 0.707 | | Duration (years) | 6.7 ± 5.7 | 6.8 ± 6.0 | 0.962 | | BMI (kg/m2) | 25.8 ± 3.7 | 25.6 ± 4.0 | 0.681 | | Systolic blood pressure (mmHg) | 138.8 ± 18.3 | 136.6 ± 22.5 | 0.498 | | Diastolic blood pressure (mmHg) | 81.2 ± 14.0 | 78.1 ± 13.2 | 0.154 | | TG (mmol/L) | 1.9 (1.3–2.8) | 1.8 (1.2–3.2) | 0.863 | | TC (mmol/L) | 5.2 ± 1.7 | 4.9 ± 1.6 | 0.251 | | LDL (mmol/L) | 3.3 ± 0.8 | 3.2 ± 0.8 | 0.548 | | HDL (mmol/L) | 1.1 ± 0.3 | 1.1 ± 0.3 | 0.936 | | HbA1c (%) | 9.6 ± 3.0 | 9.7 ± 2.5 | 0.913 | | GA (%) | 26.6 ± 19.4 | 25.5 ± 9.6 | 0.694 | | Fasting plasma glucose (mmol/l) | 8.5 ± 2.4 | 8.9 ± 2.1 | 0.267 | | 2 h glucose (mmol/L) | 13.2 ± 4.8 | 13.4 ± 6.0 | 0.766 | | Fasting serum insulin (mU/L) | 9.8 (6.2–16.4) | 10.5 (5.6–16.2) | 0.950 | | 2 h insulin (mU/L) | 38.6 (21.1–57.7) | 37.9 (20.1–70.6) | 0.793 | | FCP (ng/mL) | 1.9 (1.4–2.8) | 2.0 (1.4–3.0) | 0.830 | | 2 h CP (ng/mL) | 4.3 (2.5–7.0) | 4.3 (2.1–6.7) | 0.711 | | HOMA-IR | 3.5 (2.1–5.6) | 3.9 (2.3–6.6) | 0.594 | | HOMA-β | 41.1 (25.9–85.6) | 39.8 (19.8–72.1) | 0.187 | | HOMA-IR | 1.3 ± 0.8 | 1.3 ± 1.0 | 0.976 | | HOMA- | 3.9 ± 1.0 | 3.6 ± 0.9 | 0.179 |
|
|
|
