Research Article
GLP1R rs3765467 Polymorphism Is Associated with the Risk of Early Onset Type 2 Diabetes
Table 5
Comparison of clinical characteristics according to rs3765467 genotype after subgrouping the EOD group.
| | Parameters | GG | GA + AA | |
| | Subjects (n) | 95 | 42 | — | | Sex (M/F) | 63/32 | 22/20 | 0.121 | | Age (years) | 47.2 ± 10.0 | 46.3 ± 11.1 | 0.611 | | Duration (years) | 9.6 ± 7.7 | 8.9 ± 8.4 | 0.471 | | BMI (kg/m2) | 25.7 ± 3.6 | 26.6 ± 3.6 | 0.189 | | Systolic blood pressure (mmHg) | 132.8 ± 17.6 | 133.3 ± 19.6 | 0.870 | | Diastolic blood pressure (mmHg) | 77.6 ± 11.1 | 78.5 ± 11.3 | 0.677 | | TG (mmol/L) | 1.8 (1.3–3.0) | 2.1 (1.2–3.8) | 0.372 | | TC (mmol/L) | 5.1 ± 1.1 | 5.1 ± 2.0 | 0.816 | | LDL (mmol/L) | 3.2 ± 0.8 | 3.3 ± 0.99 | 0.551 | | HDL (mmol/L) | 1.0 ± 0.3 | 1.0 ± 0.24 | 0.648 | | HbA1c (%) | 9.3 ± 2.3 | 9.5 ± 2.1 | 0.677 | | GA (%) | 24.2 ± 7.9 | 22.4 ± 6.8 | 0.232 | | Fasting plasma glucose (mmol/l) | 8.7 ± 2.4 | 9.0 ± 2.6 | 0.614 | | 2 h glucose (mmol/L) | 11.9 ± 4.0 | 12.8 ± 3.9 | 0.256 | | Fasting serum insulin (mU/L) | 9.4 (6.2–15.3) | 11.8 (7.8–15.2) | 0.381 | | 2 h insulin (mU/L) | 37.4 (14.6–65.6) | 33.3 (21.3–52.9) | 0.882 | | FCP (ng/mL) | 1.7 (1.1–2.4) | 2.3 (1.5–2.8) | 0.042 | | 30 min CP (ng/mL) | 2.2 (1.4–3.3) | 2.7 (2.0–3.3) | 0.066 | | 2 h CP (ng/mL) | 3.0 (1.7–4.5) | 3.6 (2.4–5.7) | 0.170 | | HOMA-IR | 3.5 (2.4–5.6) | 4.5 (2.8–6.6) | 0.454 | | HOMA-β | 47.9 (23.8–71.4) | 35.6 (28.5–83.6) | 0.879 | | HOMA-IR | 1.3 ± 0.8 | 1.4 ± 0.7 | 0.497 | | HOMA- | 3.7 ± 0.8 | 3.9 ± 0.8 | 0.280 |
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