GLP1R rs3765467 Polymorphism Is Associated with the Risk of Early Onset Type 2 Diabetes
Table 3
Association between GLP1R rs3765467 polymorphism and susceptibility to diabetes.
Control
Onset age of T2DM (years)
Control vs. EOD
Control vs. LOD
≤45
>45
OR (95% CI)a
OR (95% CI)b
Allele
G
201 (69.3%)
226 (82.5%)
268 (74.9%)
1
1
A
89 (30.7%)
48 (17.5%)
90 (25.1%)
0.410 (0.262∼0.642)
<0.001
0.775 (0.534∼1.123)
0.178
Genotype
GG
70 (48.3%)
95 (69.3%)
105 (58.7%)
1
1
GA
61 (42%)
36 (26.3%)
58 (32.4%)
0.365 (0.204∼0.655)
0.001
0.679 (0.409∼1.129)
0.136
AA
14 (9.7%)
6 (4.4%)
16 (8.9%)
0.244 (0.079∼0.750)
0.014
0.742 (0.326∼1.690)
0.477
Dominant model
GG
70 (48.3%)
95 (69.3%)
105 (58.7%)
1
1
GA + AA
75 (51.7%)
42 (30.7%)
74 (41.3%)
0.365 (0.204∼0.655)
<0.001
0.679 (0.409∼1.129)
0.136
Recessive model
GG + GA
131 (90.3%)
131 (95.6%)
163 (91.1%)
1
1
AA
14 (9.7%)
6 (4.4%)
16 (8.9%)
0.667 (0.209∼2.127)
0.494
1.092 (0.467∼2.554)
0.839
OR, odds ratio; CI, confidence interval. Nonconditional logistic regression was used to calculate ORs, CIs, and corresponding values. ORa, 95% CIa, and value for comparison of the EOD and control groups (adjust for sex and BMI) . ORb, 95% CIb, and value for comparison of the LOD and control groups (adjust for sex and BMI).
